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Also worth noting: if your dog is on immunosuppressive drugs, has a compromised immune system, or is pregnant or nursing, check with your vet before starting

But doing it too much, like once every 2-3 days, can cause renal issues or pressure on the nervous system. The World Health Organization has not issued universal dosage guidelines

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Excluded or Cautioned Populations in Phase 3 Trials Phase 3 REDEFINE/REIMAGINE protocols typically excluded participants with: Type 1 diabetes

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