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When you look at the science, the chemical structure of NALT makes it a functionally weaker choice for oral supplements, despite its solubility

doi: 10.1007/s00216-017-0188-y 67 LiuXRZhangMMZhangBRempelDLGrossML

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Conclusion GLP-1RAs are potent therapies for type 2 diabetes and obesity, but their association with gallbladder disease highlights the need to better understand their effects on bile acid homeostasis and gallbladder function