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Pharmacokinetic modeling confirms this rapid onset with dose-dependent GH release (Agerso et al., 1999)

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Coupled with their high molecular weight and high polarity, it is usually difficult to penetrate the gastrointestinal epithelial cell membrane, resulting in low oral bioavailability

Phys Act Nutr 27(2):812 [DOI] [PMC free article] [PubMed] [Google Scholar] 60.Nanavati K, Rutherfurd-Markwick K, Lee SJ, Bishop NC, Ali A (2022) Effect of Curcumin supplementation on exercise-induced muscle damage: a narrative review

Mechanistically, CYB5R can transfer electrons from NADH to O 2 , leading to H 2 O 2 production and ultimately triggering ferroptosis [29]

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