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The T allele was associated with reduced risk of T2D, and increased likelihood of having been a smokerobservations that are consistent with public data
It acts on the hypothalamus, the brainstem areas involving appetite regulation, reducing the appetite, slowing gastric emptying, but it also hits the reward centers of the brainnucleus accumbens, ventral tegmental area [VTA]influencing reward-driven behaviors
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Patients who experience gastrointestinal side effects or have reduced kidney function may be better suited to alternative agents like DPP4 inhibitors, GLP1s, or SGLT2s