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[15] Calcium is another special case, in that it is required as a component of the human diet, and it is needed for the full activity of many enzymes, such as nitric oxide synthase, protein phosphatases, and adenylate kinase, but calcium activates these enzymes in allosteric regulation, often binding to these enzymes in a complex with calmodulin

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Reduced muscle mass and kidney function can also affect how vitamin B12 is stored and processed in the body

DOI: 10.1016/j.conb.2016.12.012 Kalaria RN, Harik SI (1987): Blood-brain barrier monoamine oxidase: enzyme characterization in cerebral microvessels and other tissues from six mammalian species, including human

Lewis AD, Hayes JD, Wolf CR

Anitha K, Singh MK, Kohat K, Sri Varshini T, Chenchula S, Padmavathi R, et al