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Relationship between astrocyte reactivity, using novel 11 C-BU99008 PET, and glucose metabolism, grey matter volume and amyloid load in cognitively impaired individuals

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Paradoxically, several pathways implicated in PD pathogenesisincluding glycogen synthase kinase-3 (GSK-3), p38 MAPK, and nuclear factor-B (NF-B)are upregulated and inhibit Nrf2 activity (Mogi et al., 2007

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PLoS ONE 13 , e0196233 (2018)