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Although the exact mechanisms by which GLP-1 receptor agonists mitigate ischemic injury are not fully understood, the pleiotropic mechanisms seem to extend beyond glycemic regulation, with beneficial effects observed in nondiabetic animal models, wrote first author Michael K
However, treatment with semaglutide was associated with occurrence of NAION, despite the fact that no definitive conclusions regarding this association could be drawn. Clinical Implications Semaglutide does not appear to increase or reduce risk for DR or general ocular adverse events
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