Why are GLP-1s getting cheaper while health care remains expensive
Semaglutide and tirzepatide modestly slow gut transit, which can create a favorable environment for Akkermansia growth
In a preclinical study on murine melanoma models, estrogen signalling through estrogen receptor alpha (ER) promotes the polarization of TAMs toward an immunosuppressive M2 phenotype, which impairs cytotoxic T-cell function and limits ICI efficacy
Lewis 1984;Yoshitomi, Alison, and Boorman 1986
[DOI] [PubMed] [Google Scholar] 117.Pascoe J., Jackson A., Gaskell C., Gaunt C., Thompson J., Billingham L., Steven N
This is significant because it may allow an additional reduction in liver fat, potentially helping to reduce liver inflammation and fibrosis, two causes of obesity-related complications