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doi:10.1634/theoncologist.2017-0263 Ebrahimzadeh-Ardakani, M

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For healthy adults, it's generally safe to consume up to 400mg of caffeine daily from all sources, including energy supplements

This step is generally considered the rate-limiting step, with the availability of cysteine and the expression level of GCLC jointly determining the rate of -Glu-Cys production