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Neuropharmacology 60, 740747

Soeters MR, Sauerwein HP, Faas L, Smeenge M, Duran M, Wanders RJ et al (2009) Effects of insulin on ketogenesis following fasting in lean and obese men

Gut-Derived Burden Endotoxin and microbial metabolites travel from the intestine to the liver through the portal circulation and may increase inflammatory and metabolic workload

That's a meaningful body of circumstantial evidence, but it's not the same as clinical proof of efficacy in humans

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