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Though the biological relevance of CIRTs is still largely unknown, their abundance in neuronal dendrites (and also in enucleated platelets) suggest that endogenous cytoplasmic transcripts harboring retained intronic substrates could be subject to extranuclear splicing, thereby obviating the need for shuttling molecules to and from the nucleus for processing (Buckley et al., In this order of ideas, it is tempting to speculate that CIRT in Gpx4-I gene may be part of the normal endogenous post-transcriptional regulation pathway

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[DOI] [PubMed] [Google Scholar] 210.Chen X, Yu C, Kang R, Kroemer G, Tang D