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Lactobacillus casei Shirota is found in milk, which, in one randomized clinical trial, relieved abdominal discomfort while improving stool consistency and bowel movements

Because people naturally eat less while taking these medications, they often lose weight quickly, especially in the first several months

10.1016/j.neuroscience.2008.10.041 37

The opposing responses of MCs to FN and COL I underscore the importance of ECM composition in regulating MC function, suggesting that context-dependent ECM remodeling can actively shape MC behavior, with relevance not only for MC homeostasis but potentially also for pathophysiological states and stress responses

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Indeed, some current work shows that treatment with chemical activators of the Nrf2-ARE pathway prior to the toxic insults can reduce cellular damage in the Nrf2 wildtype mice but not the Nrf2 KO 26 , 27 , 28 , 31 , 32