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Two preclinical studies showed benefits of ascorbate in a familial ALS mouse model, and there are two case reports indicated that ascorbate was associated with improvement of the disease

doi:10.1001/jamaoto.2016.1700

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Any disagreement was resolved by consensus with other coauthors

FIGURE 4 Tripeptide-1 protects skin cells against oxidative stress and enhances collagen and glycosaminoglycan (GAG) production