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Although the concept of overtourism is considered a relatively new phenomenon in the literature, studies on the impacts of tourism on settlements have been conducted in various fields since the 1960s

These are too small to form the aggregation-prone regions the paper describes

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As the brain becomes less able to control muscle movements, patients experience worsening muscle weakness and other symptoms such as difficulty breathing, speaking, and swallowing

Specifically, IC/BPS may be a bladder disorder that is part of a more generalized systemic disorder, at least in a subset of patients