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As of August 2025, we had collected over 27,885 survey respondents who had reported using at least one of Ozempic, Wegovy, compounded semaglutide, Mounjaro, Zepbound or compounded tirzepatide (Extended Data Table 1)

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Guideline recommendations for 20252026 from the ESC and ACC classify sGC stimulators as Class IIb for addressing residual risk following the four foundational pillars of HFrEF therapy (Angiotensin Receptor-Neprilysin Inhibitor (ARNI), -blocker, MRA, and SGLT2i) [85, 86]