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These adaptations can support survival and resistance to selected treatments, with effects varying by cell lineage, genotype, nutrient availability, and drug mechanism (Jyotsana et al., 2022)

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The SURMOUNT-5 trial showed tirzepatide produces about 47% more weight loss than semaglutide on average, which is 20.2% versus 13.7% body weight reduction over 72 weeks