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How GLP-1 Injections Address Perimenopause Weight Challenges How GLP-1 Injections Address Perimenopause Weight Challenges In my practice at Dr Sende Wellness in Miami, Ive observed that GLP-1 weight loss injections are particularly effective for perimenopausal women because they address multiple metabolic challenges simultaneously: Appetite Regulation Appetite Regulation GLP-1 medications work on the brains appetite centers, helping reduce hunger and food cravingsissues that often intensify during perimenopause due to hormonal fluctuations