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Indeed, numerous studies have revealed significant cellular changes in age-associated delayed healing: altered haemostasis [138, 139], reduced re-epithelialisation [140, 141], an excessive inflammatory response [142, 143] and upregulated protease activity associated with reduced matrix deposition [144]

Abbreviations FAI: Fat attenuation index PCAT: Pericoronary adipose tissue EAT: Epicardial adipose tissue T2DM: Type 2 diabetes mellitus CCTA: Coronary computed tomography angiography PSM: Propensity score matching CVD: Cardiovascular disease GLP-1RA: Glucagon-like peptide-1 receptor agonist MACE: Major adverse cardiovascular events DPP-4i: Dipeptidyl peptidase-4 inhibitor SGLT2i: Sodium-dependent glucose transporter 2 inhibitor PCSK9i: Proprotein convertase subtilisin/kexin type 9 inhibitor BMI: Body mass index FPG: Fasting plasma glucose HDL-C: High-density lipoprotein cholesterol LDL-C: Low-density lipoprotein cholesterol Lp(a): Lipoprotein a LVEF: Left ventricular ejection fraction CACS: Coronary artery calcification score Hu: Hounsfield units ROI: Region of interest RCA: Right coronary artery LAD: Left anterior descending artery LCX: Left circumflex artery References Collaborators GD

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A new study suggests that the effectiveness of widely used GLP-1 weight-loss drugs may depend strongly on consistent use

Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis

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