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The two rostral burr holes were placed just basal from the posterior interocular line, the two basal burr holes were placed just rostral to the lambdoid suture (and transverse sinuses) on both sides, respectively, and the middle two burr holes were placed in the line between the basal and rostral burr holes

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Acknowledgements This study was supported by the grants from Guangdong international cooperation program (2012B050700019) and Guangzhou Enter Nutr Bioscience Co., Ltd