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SAM is required in all organelles and has to be transported across plastidic and mitochondrial membranes, since it is synthesized only in the cytoplasm (Wallsgrove et al., 1983

(KruskalWallis test with post hoc test: Chi square = 9.705, df = 3, p = 0.021)]

The reaction system of peroxidase-like nanozymes requires the addition of H 2 O 2 , which makes the system complex, and H 2 O 2 is volatile, unstable, and easy to decompose over a long time

Nutrients 11(11)

Repeated social defeat stress induces an inflammatory gut milieu by altering the mucosal barrier integrity and gut microbiota homeostasis

Third, non-GPX4/non-RTA ferroptosis surveillance mechanisms are largely underexplored