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He had been on semaglutide for four years, with a dose increase from 0.25 to 0.5 mg weekly about four weeks prior to admission, which was associated with worsening side effects such as severe nausea and constipation
It is used in pharmaceutical and food application as dietary supplement, and found as well an application in cosmetics
Stopping is an option, but it should be a considered decision with a plan for weight maintenance, not a reflex "I've hit my goal, I'm done." For people who want to stop, a slow taper (reducing dose over 2 to 3 months) combined with aggressive protein intake, strength training, and CGM-based eating patterns gives the best chance of partial maintenance
Folch J., Lees M., Sloane Stanley G
PEG is a hydrophilic polymer that effectively reduces the adhesion between the particle and the charged components in the parenchyma of the brain (Xiao et al., 2021)