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These findings support the idea that reduced -cell mass as well as -cell dysfunction both contribute to the development and progressive course of DM

In addition, due to the ability of metformin to cross the placenta, continued use of metformin for GDM during pregnancy still raises concerns about its safety and potential adverse effects on the fetus

Substrate cleavage profiling suggests a distinct function of Bacteroides fragilis metalloproteinases (fragilysin and metalloproteinase II) at the microbiome-inflammation-cancer interface

This study is funded by the Joint construction project of Henan Medical Science and technology (LHGJ20220370) and Natural Science Foundation of Henan (232300420237)

The foundational mechanism papers from the Washington State University lab were retracted in April 2025 after a misconduct finding of image manipulation

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