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By integrating neurobiological and epigenetic perspectives, this review offers a clearer framework for understanding addiction and depression comorbidity and points to promising therapeutic opportunities

Biopsy studies have demonstrated that a longer duration of estrogen deficiency increases the risk of fibrosis in women with MASLD

Rather than viewing complexity as an inherent liability, contemporary pharmacology increasingly recognizes that pleiotropic signaling can be therapeutically advantageous when appropriately modulated through dosing, bias, and patient stratification ( 7.1 Phoenixin: integrating metabolism, reproduction, and affect Phoenixin is a relatively recently described neuropeptide identified through bioinformatic analysis of conserved peptide sequences and expressed in both central and peripheral tissues