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Youre Still in the Dose Build-Up Phase Wegovy begins at a low dose to reduce side effects, so appetite suppression may feel limited at first

For Studies 2, 3 and 4, the primary efficacy parameters were mean percent change in body weight and the percentages of patients achieving greater than or equal to 5% weight loss from baseline to week 68

Meanwhile, GLP-1 receptor activation in the hypothalamus, specifically in the arcuate nucleus and paraventricular nucleus, directly suppresses hunger signals by activating satiety-promoting POMC/CART neurons while inhibiting hunger-promoting NPY/AgRP neurons

The relationship between diabetes and weight is deeply interconnected

As you learned, these medications were originally developed for people with type 2 diabetes