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The ABR wave-I amplitude, which represents cochlear nerve activity, can provide an objective measure of cochlear synaptopathy when cochlear thresholds and associated hair cell function remain normal 16 , while the wave V, generated in the lateral lemniscus and inferior colliculus 44 , is commonly used to evaluate central auditory gain
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It has the characteristics of fewer side effects and can quickly concentrate in the brain tissue through the BBB (Palmer et al., 1994)
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