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PMID: 37445623
For evaluation of goodness of fit, we obtained the following three graphs, i.e., population predicted versus observed concentrations, weighted residuals versus time and weighted residuals versus predicted VPA concentrations
doi: 10.1056/NEJMoa054022
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Individual trials were analyzed for their quality using the Cochrane Collaborations tool for assessing the risk of bias in randomized trials ( Figure S1 ) ( Statistical Analysis The pooled estimates of the weighted mean differences (WMDs) and 95% CIs for continuous outcomes, including the changes in HbA1c and FPG, as well as the pooled risk ratios (RRs) and their 95% CIs for dichotomous outcomes, including the proportion of participants achieving target HbA1c values and the risk of hypoglycemia, were calculated
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