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Histidine persists in its neutral form between the pH of 6.00 (equivalent to pK a 3 for the side chain pyrrole NH group, which corresponds to the equilibrium between the positive and neutral form) and pH 9.17 (equivalent to pK a 2 of the amino group which corresponds to the equilibrium between the negative and neutral forms)

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Additionally, these gastrointestinal conditions could be fatal if patients do not receive proper medical attention

Recovery typically requires 12 weeks, after which metabolic management can proceed without gallbladder-specific constraints

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Maintenance treatment may be appropriate for a period, but not indefinitely for everyone