Systemic metabolic alterations and their relationship to neuropsychiatric symptomatology PAIS, including long COVID, as well as CFS and IMD, share the characteristic of systemic metabolic disturbances, which may be a sign of underlying multi-organ inflammation and exhaustion [31], and consequently may contribute to neuropsychiatric symptomatology, as many metabolites can cross the bloodbrain barrier (BBB) [30, 58] (e.g., short chain fatty acids (SCFAs) derived from the gut microbiota such as acetate [40], amino acids such as tryptophan [52] and also carnitine/acetylcarnitine can cross the BBB via transporters [59])
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Sun Y, Zhang C, Lei T, Lin F, Huang J, Hu Y, et al
Upon receipt, the hUCMSCs were thawed and transferred to DMEM/F12 medium (Gibco, Waltham, MA, USA) containing 10% FBS (Gibco) and 100 mg/mL penicillin/streptomycin
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