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The Faghihi 2021 study found that 0.6 mm performed equally well as 1.2 mm, suggesting shallower depths may be sufficient for some patients

This creates a range of new consumer behaviours and new opportunities for manufacturers to respond with differentiated products

NIK is mainly expressed in macrophages and repairing renal tubular epithelial cells (Fig S3) [29]

Individual response varies based on dosing schedule, metabolic factors, and adherence to the prescribed titration protocol

For immediate relief, over-the-counter medications such as loperamide (Imodium) or bismuth subsalicylate (Pepto-Bismol) can be effective [5]