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The downregulation of OCTN2 activity and protein expression in the kidney reduces the reabsorption of carnitine in the kidney, leading to a decrease in carnitine availability in the liver and causing hepatic lipid metabolism disorders [260]

In neuromyelitis optica, pathogenic autoantibodies target AQP4 by binding to orthogonal arrays of particles, thereby disrupting astrocyte function [415, 416]