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Finally, with the global prevalence of diabetes continuing to rise, developing innovative therapies that can reverse chronic inflammation in DW and fundamentally promote healing holds significant social and economic importance

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At the same time, the uncertainty of crosslinking degree before and after injection may lead to problems such as syringe blockage or precursor diffusion [75]

In this context, chelerythrine improves the manic-like manifestations and reverses the decreased cell proliferation in the hippocampus (Galeotti and Ghelardini, 2011)