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Reassessing the Mechanisms of Acute Coronary Syndromes

The following are known triggers of mast cell degranulation (in addition to IgG activation via pathogen or allergen):[ref] Acetylcholine Complement fragments (C3, C4, C5) Various drugs, environmental toxins (MRGPRX2 receptor, details below) Peptides (including endorphin, leptin, PTH, and more) Physical conditions (cold, heat, pressure, stress, and vibration)

doi: 10.1101/cshperspect.a041163 35

May 2007;85(5):1428-1433

Things to Consider: The spray form might not be for everyone

Tamoxifen-resistant ZR-75-1 cells were cultured in phenol-red free DMEM (Sigma, Darmstadt, Germany) supplemented with 10% DCC, 100 units/mL penicillin, 100 g/mL streptomycin and 5 M Tamoxifen