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Although there have been no specific trials to show cardiorenal benefit for GLP-1RA or SGLT2i when used as first-line therapy or as monotherapy or in newly diagnosed T2D, the benefit seen in the CV outcome trials has not been found to vary with the duration of diabetes, suggesting that similar benefits might be seen early in the course of disease.4 The benefits are also not dependent on the presence of metformin

Non-selective agonist at MC3R and MC4R, supporting studies of central melanocortin signaling distinct from peripheral vasoactive mechanisms

Further larger studies are therefore needed to assess the impact of GLPR1a on EAT and their impact on LV function

There is also an oral solution available for pediatric populations

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