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Diabetic retinopathy problems: Changes in vision in those with Type 2 diabetes, particularly vision problems, may worsen in those with a history of diabetic retinopathy

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A direct effect of tirzepatide at the GIPR in adipose tissue surrounding and within the kidney, such as perirenal fat and intrarenal fat, may favorably affect inflammation known to contribute to kidney dysfunction

Approved Uses and Potential New Benefits Currently, GLP-1 receptor agonists are approved for managing diabetes, obesity, and cardiovascular disease in overweight individuals

Variants in genes affecting glutathione metabolism, oxidative stress responses, and metabolic inflammation may help provide context for why certain patients respond more robustly to supplementation strategies

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