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Horny Goat Weed (Epimedium) Most research is animal or lab-based

Figure 6 Apart from the canonical TGF-1/Smad2/3-signaling TGF- can signal via non-canonical pathways

Receptor activation initiates intracellular pathways including PI3K/Akt and MAPK signalling cascades, which regulate cellular proliferation, protein synthesis, metabolic activity, and apoptosis resistance

Leombruni P 1 , Miniotti M 1 , Colonna F 1 , Sica C 1 , Castelli L 2 , Bruzzone M 3 , Parisi S 3 , Fusaro E 3 , Sarzi-Puttini P 4 , Atzeni F 5 , Torta RG 1

For amyloid plaque staining, briefly brain sections were deparaffinized and rehydrated according to standard protocol