Dexrazoxane (DXZ), the only FDA-approved agent for preventing doxorubicin (DOX)-induced cardiotoxicity, exerts its protective effects by chelating mitochondrial iron and mitigating oxidative stress [37]
10.1089/cap.2012.0127 29 LairdN
Alternatively, and more recently, gold-based fluorescent nanoclusters (AuNCs) attracted a significant interest as an ultrasmall inorganic nanoprobes (core size less than 2 nm) with stable photoluminescence properties 13,14,15,16
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Overproduction of NO can occur in several pathological conditions (e.g., inflammation, endotoxic shock, diabetes, ischemia/reperfusion injury