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In the trial, researchers enrolled more than 700 obese people with the heart failure condition

Semaglutide carries a boxed warning for risk of thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), and is contraindicated in patients with a personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

The chart below from Weight regain and cardiometabolic effects after withdrawal of semaglutide also show a rapid regain after stopping the drugs

During FDA-declared shortages, its legal for pharmacists to make compounded versions of brand-name drugs in shortage, though drugmakers have vehemently pushed back against the legitimacy of this practice

doi: 10.1016/j.appet.2020.105054, 20 ColvinK

The good news is that these symptoms usually improve significantly as tolerance develops, often within 48 weeks of consistent use