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, Highly palatable diet consumption increases protein oxidation in rat frontal cortex and anxiety-like behavior

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Specifically, we tested the prevalent but unsubstantiated hypothesis that peripheral GLP-1 signals to the brain to suppress eating via vagal and/or endocrine activation of central GLP-1-producing preproglucagon (PPG) neurons, i.e

Consistently, HIF1A also promotes GSH synthesis through transcriptional activation of GCLM and SLC7A11 , and pharmacological inhibition of SLC7A11 with erastin or sorafenib exacerbates cuproptosis 177,178

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