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Real-time parameters of the cellular respiration or oxidative metabolism can be measured in the hepatic cells by extracellular flux assays by measuring oxygen consumption and extracellular acidification rates, and similar studies found no significant difference between absolute ATP synthesis rates between CFS and control cells (Tomas et al

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222 Aside from the potential for systemic oxalosis, concern is also warranted because a pro-oxidant effect of high-dose vitamin C, either directly or through its effects on mobilization of iron, has been reported

The best type of intervention that should be recommended is unclear since all the successful programs used different exercise modalities in terms of intensity, type, duration and frequency