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BioMed Res Int (2017) 2017:16

Brain Research Bulletin, 126 (1), 29-40

Success in all antibacterial therapies depends on susceptibility to given drugs, doses, formulations, use of adjuvants (agents that demonstrate additive and/or synergistic effect with antibiotic therapy), treatment duration, and reinfection rates

The use of miRNAs to modulate the expression of the mutant A1AT gene and reduce the associated toxic effects has also been explored

Regular checks are needed to adjust the treatment plan