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The results indicated that melatonin lightened the hyperpigmented skin of one patient with untreated adrenogenital syndrome but had no effect on the skin of other patients with idiopathic hyperpigmentation or treated Addison's disease1

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Relative gene expression was assessed by quantitative PCR (qPCR) on an ABI PRISM 7500 system (Applied Biosystems, Warrington, UK) using SYBR Green PCR Master Mix (Applied Biosystems)

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