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The peroxisome proliferator-activated receptor gamma (PPAR) pathway-which regulates macrophage polarizationis suppressed, further favoring M1 polarization (95, 96)
It has also been found that neuroinflammation within the dorsal root ganglion (DRG) may upregulate FcRI (a key immune receptor) signaling after regression of joint inflammation in a mouse model of collagen antibody-induced arthritis (CAIA), and that knocking down the expression of Fcgr1 in the DRG produces a similar analgesic effect and reduces persistent pain (Liu et al., 2022)
Alan Rogol, a pediatric endocrinologist at Riley Hospital for Children in Indianapolis
It has been recognized that the APAP toxicity consists of multi-stages and multi-signaling pathways, including APAP metabolism, oxidative stress, endoplasmic reticulum (ER) stress, autophagy, sterile inflammation, microcirculatory dysfunction, and compensatory liver repair and regeneration
Cells 12 , 500 (2023)
