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In conclusion, we revealed novel structurefunction relationships of glutaredoxins, gained insights regarding the enzymatic conversion of glutathione- and non-glutathione disulfide substrates, and identified two distinct substrate interaction sites that include a scaffold residue and the conserved dual activator Lys105 in ScGrx7 and Lys26 in PfGrx

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The evidence presented highlights how chronic ethanol consumption contributes to the onset of depressive disorders through various pathways, including the escalation of oxidative stress, the promotion of neuroinflammation, and the dysregulation of neurotrophic factors

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