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Because the combination of CJC-1295 and Ipamorelin utilizes natural physiologic pathways and preserves the negative feedback loop, it does not cause the severe receptor downregulation associated with direct hGH

A genome-wide DNA methylation profiling study showed that Fgf16 , Fgf17 , Fgf20 and Fgfr4 are highly methylated in cultured astrocytes (Meissner et al., 2008)