semaglutide hold before surgery the Ozempic surgery, US doctors say Should Ozempic (semaglutide) be held

GLP-1 agonists enhance insulin secretion from pancreatic beta cells only when blood glucose levels are elevated, a mechanism termed "glucose-dependent insulinotropic action." This physiological approach reduces the risk of hypoglycemia compared with sulfonylureas or exogenous insulin, though the risk increases when GLP-1 agents are combined with insulin or sulfonylureas, potentially requiring dose adjustments of these medications

One can also argue that other parameters of nAbs such as effector function should be evaluated

Compounded semaglutide is not FDA-approved in the same way as branded formulations

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doi: 10.1038/sj.jcbfm.9600351