3.4 Metformin and doxorubicin-induced cardiotoxicity Doxorubicin (DOX), a potent anthracycline chemotherapeutic, is widely used in oncology but its clinical utility is limited by dose-dependent cardiotoxicity
Anything that enters the eye, from drops to foreign particles, can easily make its way into the bloodstream
Melatonin, on the other hand, activates both the Nrf2ARE and AMPKSIRT1 pathways, leading to upregulation of antioxidant enzymes such as HO-1, NQO1, and SOD, stabilization of mitochondrial membrane potential, and inhibition of cytochrome c release (84, 85)
The ratio of GSH/GSSG is 300 to 600, which corresponds to a redox potential ( Eo ) of 240 mV, assuming a total intracellular GSH of 5 mM, pH 7.0, and 25
New research shows that eating animal products causes animal sugars, such as Neu5Gc, to become attached to cells that line our hollow organs, like the stomach, causing the body to make antibodies against these sugars resulting in chronic inflammation and, therefore, impaired B12 absorption
FEMS Yeast Res., 2002, 2, 295-305