101 Hyperactivation of the PI3K pathway, a lipid kinase that promotes proliferation and nutrient uptake in response to growth signals, has been implicated in breast and endometrial cancers, providing a possible mechanism for hormonal therapy evasion
Any exciting breakthroughs that were on the cusp of
The kinetics of transport inhibition by noncompetitive inhibitors
When a patient presents for fertility investigation, a non-invasive diagnostic ultrasound scan may detect endometriosis but also permits assessment of both ovarian reserve (antral follicle count) and ovarian accessibility for oocyte retrieval
What dysesthesia looks like: Tingling or "pins and needles" sensations, most commonly in hands, feet, or face Altered temperature sensation Burning or prickling sensations Onset typically during dose escalation (weeks 416) but can occur later Severity: Most cases were mild and didn't lead to treatment discontinuation
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