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photodynamic therapy (PDT) and immune memory, hemoglobin iron combined with PDT activate CD8+ T cells to release IFN- to induce ferroptosis, while the nano photosensitizer MAR releases tumor-associated antigens (TAAs) through ferroptosis, which increases the maturation rate of dendritic cells (DCs) and forms long-lasting anti-tumor immune memory (222, 224)

Because this pathway is distinct from GLP-1 signaling, cagrilintide is studied in combination with GLP-1 receptor agonists such as semaglutide, where the two mechanisms are reported to produce additive appetite suppression

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Oct 2001;77(2-3):203-8

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