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88 In recent years, studies have revealed that UA activates the TLR4-NLRP3 inflammatory complex, which is a multi-protein complex that plays a pivotal role in initiating the innate immune response to various danger signals, including MSU crystals

188 These genes are specifically expressed on the apical membrane of renal proximal tubule cells, which are crucial for the secretion of uric acid into the glomerular filtrate, as depicted in Fig

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However, research is still ongoing, and results may vary

All the samples were prepared at a protein concentration of 1 mg/ml in a buffer containing 50 mM sodium phosphate (pH 7.8) and 150 mM NaCl