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Regional Cerebral Blood Flow (rCBF) Monitoring Using Laser Doppler Flowmetry (PeriFlux 5,000, Perimed, Sweden) over the right MCA territory, rCBF was recorded immediately before and after ET-1 injection: Successful Ischemia: A reduction in rCBF to 30% of the baseline value within 5 min of ET-1 administration

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Conversely, conditions causing rapid gastric transit or malabsorption might theoretically affect drug uptake, though this is less well-documented given the subcutaneous route of administration for most GLP-1 therapies